SigProfilerExtractor allows de novo extraction of mutational signatures from data generated in a matrix format. The tool identifies the number of operative mutational signatures, their activities in each sample, and the probability for each signature to cause a specific mutation type in a cancer sample. The tool makes use of SigProfilerMatrixGenerator and SigProfilerPlotting.
active 2024-08-31 → 2026-01-22 (UTC)
Activity over time
Daily event counts in the loaded window
Line chart, 510 days from 2024-08-31 to 2026-01-22. Pushes: 11 total, peak 2 in a day. Pull requests: 9 total, peak 2 in a day. Issues: 16 total, peak 2 in a day. Comments: 13 total, peak 4 in a day. Stars: 11 total, peak 1 in a day.
- Pushes
- Pull requests
- Issues
- Comments
- Stars
Stars, PRs, issues and forks are under-captured in the later part of this window. GH Archive progressively stopped capturing non-push events during 2026 — −95% or worse by the end of the window. Every series here except Pushes fades for that reason, so a decline above reflects the archive, not this repository. Pushes stay reliable throughout, so read them, and the contributor counts derived from them, as the real signal. Data health has the measurements.
Top contributors
Pushes, PRs, issues, reviews and comments — stars and forks excluded, so this is contribution rather than popularity
| Contributor | Contributions | Pushes | PRs | Comments |
|---|---|---|---|---|
| mdbarnesUCSD | 34 | 11 | 9 | 8 |
| DittmanC | 3 | 0 | 0 | 2 |
| kbrar4013 | 2 | 0 | 0 | 2 |
| shenhaizhongdechanrao | 2 | 0 | 0 | 0 |
| syparkmd | 1 | 0 | 0 | 0 |
| saikatbib | 1 | 0 | 0 | 1 |
| Matteo-Paini | 1 | 0 | 0 | 0 |
| Frank1219 | 1 | 0 | 0 | 0 |
| yingqizhang | 1 | 0 | 0 | 0 |
| thisisliuyu | 1 | 0 | 0 | 0 |
| robert-a-forsyth | 1 | 0 | 0 | 0 |
| MousumyCSE | 1 | 0 | 0 | 0 |
Recent activity
Latest issues, pull requests and releases
- Issue#292mdbarnesUCSD2026-01-20 21:49Question about the use of reference genome mm39
- Issue comment#292mdbarnesUCSD2026-01-20 21:49Question about the use of reference genome mm39
- Issue comment#296DittmanC2026-01-10 14:44unable to download the reference genome
- Issue comment#282DittmanC2026-01-10 14:43cannot get reference
- Issue#296DittmanC2026-01-10 13:19unable to download the reference genome
- Issue#294Frank12192025-12-11 14:12SV KeyError: 'none'
- Issue comment#292saikatbib2025-11-18 05:06Question about the use of reference genome mm39
- Issue#287mdbarnesUCSD2025-11-14 16:54Questions about de novo signature and parameter setting in SigProfiler
- Pull request#291mdbarnesUCSD2025-10-29 06:27
- ReleasemdbarnesUCSD2025-10-29 03:09v1.2.5
- Pull request#290mdbarnesUCSD2025-10-29 02:20
- Issue comment#285mdbarnesUCSD2025-10-29 02:19create a custom reference
- Issue#285mdbarnesUCSD2025-10-29 02:19create a custom reference
- ReleasemdbarnesUCSD2025-10-21 07:14v1.2.4
- ReleasemdbarnesUCSD2025-09-19 23:51v1.2.3
- Pull request#284mdbarnesUCSD2025-09-19 23:49
- Issue comment#275mdbarnesUCSD2025-09-15 17:04Feature Request: Support for Checkpoint/Resume (Breakpoint Restart) Functionality
- Issue comment#280mdbarnesUCSD2025-09-15 17:02CHM13 Reference Genome
- Issue#280mdbarnesUCSD2025-09-15 17:02CHM13 Reference Genome
- Issue comment#282mdbarnesUCSD2025-09-15 16:55cannot get reference
- Issue comment#281mdbarnesUCSD2025-09-15 16:51Question about the exome parameter for WES data
- Issue#281thisisliuyu2025-09-15 03:18Question about the exome parameter for WES data
- Issue#280robert-a-forsyth2025-08-28 08:05CHM13 Reference Genome
- Pull request#279mdbarnesUCSD2025-08-13 18:18
- Pull request#278mdbarnesUCSD2025-08-08 21:17
Totals cover only the window loaded into ClickHouse and count events, not GitHub's lifetime totals — 11 stars here means stars gained during the window, not the repo's star count.