SigProfilerSimulator allows realistic simulations of mutational patterns and mutational signatures in cancer genomes. The tool can be used to simulate signatures of single point mutations, double point mutations, and insertion/deletions. Further, the tool makes use of SigProfilerMatrixGenerator and SigProfilerPlotting.
active 2023-09-26 → 2026-01-20 (UTC)
Activity over time
Daily event counts in the loaded window
Line chart, 848 days from 2023-09-26 to 2026-01-20. Pushes: 9 total, peak 2 in a day. Pull requests: 3 total, peak 1 in a day. Issues: 8 total, peak 2 in a day. Comments: 8 total, peak 2 in a day. Stars: 2 total, peak 1 in a day.
- Pushes
- Pull requests
- Issues
- Comments
- Stars
Stars, PRs, issues and forks are under-captured in the later part of this window. GH Archive progressively stopped capturing non-push events during 2026 — −95% or worse by the end of the window. Every series here except Pushes fades for that reason, so a decline above reflects the archive, not this repository. Pushes stay reliable throughout, so read them, and the contributor counts derived from them, as the real signal. Data health has the measurements.
Top contributors
Pushes, PRs, issues, reviews and comments — stars and forks excluded, so this is contribution rather than popularity
| Contributor | Contributions | Pushes | PRs | Comments |
|---|---|---|---|---|
| mdbarnesUCSD | 15 | 7 | 3 | 2 |
| cutleraging | 6 | 0 | 0 | 3 |
| MousumyCSE | 4 | 2 | 0 | 2 |
| e-coral | 1 | 0 | 0 | 1 |
| cdupai-bbi | 1 | 0 | 0 | 0 |
| robert-a-forsyth | 1 | 0 | 0 | 0 |
Recent activity
Latest issues, pull requests and releases
- Issue#14mdbarnesUCSD2025-12-18 21:51T2T support
- Issue comment#14mdbarnesUCSD2025-12-18 21:51T2T support
- Issue comment#14e-coral2025-12-15 08:30T2T support
- Issue#14robert-a-forsyth2025-08-28 07:55T2T support
- Issue#11mdbarnesUCSD2025-05-27 19:40u70: SigProfilerSimulator Seeds Support
- ReleasemdbarnesUCSD2025-05-27 19:40v1.2.2
- Pull request#13mdbarnesUCSD2025-05-27 19:38
- Issue comment#5MousumyCSE2024-09-24 18:41Lower mutation number in simulation than observed
- ReleasemdbarnesUCSD2024-03-21 22:01v1.1.6
- Pull request#8mdbarnesUCSD2024-03-21 22:00
- Issue#7cdupai-bbi2024-01-19 18:59Hard-coded chromosomes make it impossible to run code with "chr" prefix for chromosome IDs or "MT" chromosomes
- Issue comment#5cutleraging2024-01-05 22:42Lower mutation number in simulation than observed
- Issue comment#6mdbarnesUCSD2024-01-04 18:01Chromosome based error
- Issue comment#5cutleraging2024-01-03 00:02Lower mutation number in simulation than observed
- Issue#5cutleraging2024-01-03 00:02Lower mutation number in simulation than observed
- Issue comment#5cutleraging2024-01-03 00:01Lower mutation number in simulation than observed
- Issue#5cutleraging2024-01-03 00:01Lower mutation number in simulation than observed
- Issue#6cutleraging2024-01-02 22:15Chromosome based error
- Issue comment#5MousumyCSE2023-12-22 03:09Lower mutation number in simulation than observed
- Issue#3mdbarnesUCSD2023-09-29 20:58Update SigProfilerSimulator for Changes in SigProfilerMatrixGenerator Imports
- Pull request#4mdbarnesUCSD2023-09-29 20:53
Totals cover only the window loaded into ClickHouse and count events, not GitHub's lifetime totals — 2 stars here means stars gained during the window, not the repo's star count.