This is the offical codebase to reproduce and use EVOLVEpro, a model for in silico directed evolution of protein activities using few-shot active learning.
active 2024-07-19 → 2026-05-19 (UTC)
Activity over time
Daily event counts in the loaded window
Line chart, 670 days from 2024-07-19 to 2026-05-19. Pushes: 60 total, peak 9 in a day. Pull requests: 9 total, peak 3 in a day. Issues: 87 total, peak 5 in a day. Comments: 77 total, peak 5 in a day. Stars: 289 total, peak 25 in a day.
- Pushes
- Pull requests
- Issues
- Comments
- Stars
Stars, PRs, issues and forks are under-captured in the later part of this window. GH Archive progressively stopped capturing non-push events during 2026 — −95% or worse by the end of the window. Every series here except Pushes fades for that reason, so a decline above reflects the archive, not this repository. Pushes stay reliable throughout, so read them, and the contributor counts derived from them, as the real signal. Data health has the measurements.
Top contributors
Pushes, PRs, issues, reviews and comments — stars and forks excluded, so this is contribution rather than popularity
| Contributor | Contributions | Pushes | PRs | Comments |
|---|---|---|---|---|
| mat10d | 142 | 54 | 5 | 51 |
| yueli8 | 8 | 0 | 0 | 4 |
| idmjky | 6 | 6 | 0 | 0 |
| sma1-rmarud | 4 | 0 | 1 | 0 |
| CrazyHsu | 4 | 0 | 0 | 2 |
| lyh951024 | 3 | 0 | 0 | 0 |
| Yoonseopark02 | 3 | 0 | 0 | 1 |
| abzb1 | 3 | 0 | 1 | 1 |
| willwzc | 3 | 0 | 0 | 1 |
| chaofan520 | 3 | 0 | 0 | 1 |
| subhansb8 | 3 | 0 | 0 | 1 |
| Hai-W-L | 2 | 0 | 0 | 2 |
| Alive-D | 2 | 0 | 0 | 0 |
| mulatta | 2 | 0 | 1 | 1 |
| G-dragondragon | 2 | 0 | 0 | 1 |
| tangweijr | 2 | 0 | 0 | 0 |
| zxianren | 2 | 0 | 0 | 1 |
| haonanzc | 2 | 0 | 0 | 0 |
| nbb116 | 2 | 0 | 0 | 1 |
| jiangshiyi-c | 2 | 0 | 0 | 1 |
Recent activity
Latest issues, pull requests and releases
- Issue comment#59mulatta2026-02-04 05:50Fix lazy torch
- Pull request#59mulatta2026-02-04 05:47
- Issue comment#55mat10d2025-10-29 02:23Inputing activity data from Multi-mutant
- Issue comment#57mat10d2025-10-29 02:19input experimental data as relative values normalized to WT?
- Issue comment#56mat10d2025-10-29 02:16KeyError 'iteration' in directed_evolution_simulation when running DMS workflow
- Issue#57lyh9510242025-10-29 02:11input experimental data as relative values normalized to WT?
- Issue comment#54mat10d2025-08-31 23:46Workflow for single vs multi-mutant embeddings
- Issue#53sma1-rmarud2025-08-25 01:57[Usage Question] Predicting activity for multiple mutants using generated combinations and embeddings
- Issue comment#46mat10d2025-08-23 19:10How can I reproduce the results shown in the paper?
- Issue comment#53mat10d2025-08-23 19:02[Usage Question] Predicting activity for multiple mutants using generated combinations and embeddings
- Issue comment#52mat10d2025-08-23 19:00Can evolvepro be utilized in biomaterial domain?
- Issue#53sma1-rmarud2025-07-31 06:13[Usage Question] Predicting activity for multiple mutants using generated combinations and embeddings
- Issue comment#16Hai-W-L2025-07-16 06:01how to generate 2nd and 3rd embeddings?
- Issue comment#46chengaaaaasacs2025-07-15 19:35How can I reproduce the results shown in the paper?
- Issue comment#46mat10d2025-06-11 20:55How can I reproduce the results shown in the paper?
- Issue#47mat10d2025-06-11 20:53[Bug] Non-deterministic ordering from `os.walk()` causes inconsistent Top Variants
- Issue comment#47mat10d2025-06-11 20:53[Bug] Non-deterministic ordering from `os.walk()` causes inconsistent Top Variants
- Issue comment#48mat10d2025-06-11 20:48fix to sort esm extracted features
- Pull request#48mat10d2025-06-11 20:48
- Pull request#51mat10d2025-06-11 20:46
- Pull request#50sma1-rmarud2025-06-11 05:08
- Issue#49chaofan5202025-06-06 00:34Question about Fig 1.d
- Issue comment#49chaofan5202025-06-06 00:34Question about Fig 1.d
- Issue#49chaofan5202025-06-06 00:33Question about Fig 1.d
- Issue comment#47abzb12025-05-31 23:24[Bug] Non-deterministic ordering from `os.walk()` causes inconsistent Top Variants
Totals cover only the window loaded into ClickHouse and count events, not GitHub's lifetime totals — 289 stars here means stars gained during the window, not the repo's star count.