VUStruct analyses sets of Variants of Unknown Significance (VUSs) by contextualizing them in 3D protein structural space.
active 2025-02-26 → 2026-05-04 (UTC)
Activity over time
Daily event counts in the loaded window
Line chart, 433 days from 2025-02-26 to 2026-05-04. Pushes: 23 total, peak 4 in a day. Pull requests: 7 total, peak 4 in a day. Issues: 37 total, peak 22 in a day. Comments: 17 total, peak 15 in a day. Stars: 1 total, peak 1 in a day.
- Pushes
- Pull requests
- Issues
- Comments
- Stars
Stars, PRs, issues and forks are under-captured in the later part of this window. GH Archive progressively stopped capturing non-push events during 2026 — −95% or worse by the end of the window. Every series here except Pushes fades for that reason, so a decline above reflects the archive, not this repository. Pushes stay reliable throughout, so read them, and the contributor counts derived from them, as the real signal. Data health has the measurements.
Top contributors
Pushes, PRs, issues, reviews and comments — stars and forks excluded, so this is contribution rather than popularity
| Contributor | Contributions | Pushes | PRs | Comments |
|---|---|---|---|---|
| ChrisMoth | 84 | 23 | 7 | 17 |
Recent activity
Latest issues, pull requests and releases
- Pull request#130ChrisMoth2026-01-13 19:11
- Issue#128ChrisMoth2026-01-12 23:13Migrate to Python 3.11 and venv
- Issue comment#112ChrisMoth2025-07-09 15:39Website should show health statistics, versioning info
- Issue#124ChrisMoth2025-06-25 18:49Support vustruct input files without refseq column
- Issue#123ChrisMoth2025-06-25 18:48Skip DiGePred and DIEP runs for single-gene inputs
- Issue#120ChrisMoth2025-06-04 21:26PPI Calculations may be misloading AF structures
- Issue#119ChrisMoth2025-05-14 02:40In psb_plan.py, do not load Alphafold pLDDTs until alignment checked
- Issue#118ChrisMoth2025-04-25 15:14Update protein domain annotations
- Issue#117ChrisMoth2025-04-23 21:59Reduce Musite PTM calculations' Alphafold dependency
- Issue comment#95ChrisMoth2025-03-31 15:06Integrate failure messages, and all logs into web outputs
- Issue#95ChrisMoth2025-03-31 15:06Integrate failure messages, and all logs into web outputs
- Issue#93ChrisMoth2025-03-31 15:05Build case monitor to flask applications and website
- Issue comment#93ChrisMoth2025-03-31 15:05Build case monitor to flask applications and website
- Issue#76ChrisMoth2025-03-31 15:04Clearer errors messages when ddg fails due to a wt mismatch
- Issue#75ChrisMoth2025-03-31 15:03ddg_cartesian relax results not re-used correctly
- Issue comment#69ChrisMoth2025-03-31 15:03Support Wash U St. Louis Input Format
- Issue#116ChrisMoth2025-03-31 15:02Integrate Boltz-1 and Chai open source models. Complexes
- Issue#83ChrisMoth2025-03-31 14:59Move pathprox3 substitution weightings to BLOSUM90 from old style matrices (pairwise2 is deprecated)
- Issue#115ChrisMoth2025-03-31 14:58Document all input formats better on website
- Issue#94ChrisMoth2025-03-31 14:57Replace case_missense.csv format with extended case_vustruct.csv and include all genes
- Issue comment#89ChrisMoth2025-03-31 14:56Integrate Alican Gulsevin's MusiteDeep PTM, ScanNet PPI, and DIEP protocols into pipeline
- Issue comment#71ChrisMoth2025-03-31 14:56Faster psb_plan; Use SIFTS, not Uniprot IDMapping, to get "best structures" for a given uniprot ID
- Issue comment#82ChrisMoth2025-03-31 14:55Set group -rw ownerships via config file
- Issue comment#73ChrisMoth2025-03-31 14:54Genes lacking structures should always appear with empty reports.
- Issue#72ChrisMoth2025-03-31 14:53Log "info", not "warn" on cases of VEP returning transcripts unknown to uniprot
Totals cover only the window loaded into ClickHouse and count events, not GitHub's lifetime totals — 1 stars here means stars gained during the window, not the repo's star count.