SigProfilerExtractor allows de novo extraction of mutational signatures from data generated in a matrix format. The tool identifies the number of operative mutational signatures, their activities in each sample, and the probability for each signature to cause a specific mutation type in a cancer sample. The tool makes use of SigProfilerMatrixGenerator and SigProfilerPlotting.
active 2026-01-22 → 2026-07-31 (UTC)
Activity over time
Daily event counts in the loaded window
Line chart, 191 days from 2026-01-22 to 2026-07-31. Pushes: 12 total, peak 3 in a day. Pull requests: 1 total, peak 1 in a day. Issues: 3 total, peak 3 in a day. Comments: 8 total, peak 3 in a day. Stars: 4 total, peak 1 in a day.
- Pushes
- Pull requests
- Issues
- Comments
- Stars
Stars, PRs, issues and forks are under-captured in the later part of this window. GH Archive progressively stopped capturing non-push events during 2026 — −95% or worse by the end of the window. Every series here except Pushes fades for that reason, so a decline above reflects the archive, not this repository. Pushes stay reliable throughout, so read them, and the contributor counts derived from them, as the real signal. Data health has the measurements.
Top contributors
Pushes, PRs, issues, reviews and comments — stars and forks excluded, so this is contribution rather than popularity
| Contributor | Contributions | Pushes | PRs | Comments |
|---|---|---|---|---|
| mishugeb | 21 | 12 | 1 | 5 |
| mp15 | 1 | 0 | 0 | 1 |
| steverozen | 1 | 0 | 0 | 1 |
| jiridanek | 1 | 0 | 0 | 1 |
Recent activity
Latest issues, pull requests and releases
- Issue comment#203mp152026-05-27 10:37GPU-enabled run failed
- Pull request#305mishugeb2026-05-24 23:39
- Issue comment#287mishugeb2026-05-09 03:43Questions about de novo signature and parameter setting in SigProfiler
- Issue comment#304mishugeb2026-05-09 03:27cannot reindex on an axis with duplicate labels
- Issue comment#301steverozen2026-05-03 00:20please fix sigprofilerextractor crashes when updating to latest pandas 2.0+
- Issue#274mishugeb2026-04-18 04:08Question about nmf_init parameter options in SigProfilerExtractor
- Issue comment#274mishugeb2026-04-18 04:08Question about nmf_init parameter options in SigProfilerExtractor
- Issue#233mishugeb2026-04-18 04:04Singularity container creation
- Issue#299mishugeb2026-04-18 04:02Licensing discrepancy
- Issue comment#299mishugeb2026-04-18 04:02Licensing discrepancy
- Issue comment#300mishugeb2026-04-18 03:59Release 1.2.7 request
- Issue comment#300jiridanek2026-03-17 20:08Release 1.2.7 request
Totals cover only the window loaded into ClickHouse and count events, not GitHub's lifetime totals — 4 stars here means stars gained during the window, not the repo's star count.